The rivalries, romances, hopes and fears of the residents of the fictional Midwestern metropolis, Genoa City. The lives and loves of a wide variety of characters mingle through the generations, dominated by the Newman, Abbott, Baldwin and Winters families.

Over a long weekend, John & Marlena travel to Zurich, Ben & Ciara have a romantic getaway in New Orleans, Chad visits some old friends in Phoenix, and Abe, Paulina, Lani, and Eli vacation in Miami. All find themselves embroiled in a mystery involving stolen jewels which, in the wrong hands, could cause dire consequences for Salem.